more new connective tissue and collagen at the scar area. For the first time, the method of subcision therapy with cannula in patients with acne scars was performed by Dr. Nilforoushzadeh and the result of this research was published. The second clinical trial was done by Dr. Nilforoushzadeh and his research group on the 100 patients “comparing cannula based subcision with the common needle method “and the result of this case series was published in Wiley Journal . Now, in collaboration with the Jordan Clinic and the Skin and Stem Cell Research Center in Tehran University of Medical Sciences , the new clinical trial’s method ( cannula based subcision plus cell therapy ) is underway