Date of Release: 2004

Efficacy of combined triple therapy (paramomycin ointment, cryotherapy and intralesional glucantime) in comparison with intralesional glucantime for the treatment of acute cutaneous leishmaniasis

Background: In spite of different methods of treatment, there is not a simple, safe and complete curative treatment for cutaneous leishmaniasis (CL), yet Objective: To compare the efficacy of intralesional Glucantime injection alone, with the combined triple therapy of cryotherapy, paramomycm ointment and intralesional Glucantime in the treatment of CL. Patients & Methods: 157 patients with CL were randomly allocated into two groups, 81 patients in group I were injected with intralesional Glucantime (twice a week up to healing of the lesions or maximum 6 weeks). 76 patients in group 2 were treated with paramomycin ointment (15% in 10% urea, twice a day), cryotherapy (maximum 3 times 2 weeks apart and injection of intralesional Glucantime (once a week), for the same period as group 1 Results: After 6 weeks, complete cure rate in group 2 (89.5%) was significantly more than group 1 (70.4%) (P<0.05) Conclusion: Our results indicating of more efficacy of the triple therapy is in accordance with the previous studies of combined cryotherapy and paramomycin. It could be recommended as a better treatment modality for CL wherever possible
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