The Role of Wharton’s Jelly Mesenchymal Stem Cells in Skin Reconstruction

Context: Stem cell therapy, especially in the segment of mesenchymal stem cells (MSCs), is one of the most promising areas of regenerative medicine

Evidence Acquisition: According to research conducted by various researchers, Wharton’s Jelly mesenchymal stem cells (WJMSCs) have several advantages compared to others sources, in regenerative medicine: WJMSCs are more primary cells; WJMSCs can be easily isolated and without invasive procedures; WJMSCs have no ethical problems; WJMSCs are more cost effective than other sources of MSCs. Also, WJMSCs were demonstrated to express stem cell mesenchymal markers

Results: Similar to bone marrow MSCs, WJMSCs express major histocompatibility complex (MHC) class I molecules

Conclusions: Although the aforementioned challenges must still be addressed, the potential of WJMSCs in skin regenerative clinical treatments is promising