Background: Lasers and light-based treatments are currently the standard and useful methods for treating various stages of aging. Several studies have shown that the most successful results in treating wrinkles are achieved via combination of different treatment protocols. In this study, we compared the efficacy and patient satisfaction in treatment of facial static wrinkles using CO2 fraxel laser alone or with radiofrequency Methods: In this clinical trial study, 50 patients with the inclusion criteria were randomly selected from Novin Laser Clinic, Isfahan, Iran, and divided into two groups. Group I were treated with CO2 fraxel laser and group II were treated with CO2 fraxel laser and radiofrequency. 3 and 6 months after the treatment, clinical improvement and patient satisfaction were evaluated and compared between the groups Findings: 3 and 6 months after the treatment, patient satisfaction and clinical improvement were not significantly different between the two studied groups treated with CO2 fraxel laser alone or with radiofrequency Conclusions: According to our findings, adding radiofrequency to the treatment of facial static wrinkles with CO2 fraxel laser does not any effect on patient satisfaction and clinical improvement. More studies on patients with different skin types could be useful