Background: This study aimed to compare the efficacy of CO2 and Fraxel lasers on healing of the wound and the size of cutaneous leishmaniasis scars Methods: In this randomized clinical trial study, 120 patients were randomly devided in two equal groups underwent CO2 and Fraxel lasers in treatment of leishmaniasis scars, respectively. In all cases, size and other aspects of scar were evaluated using a checklist before and 1, 3, and 6 months after the treatment Findings: The patients’ mean age was 27.21±11.20 years. At the third and sixth months after the treatment, the healing rate of scars was statistically better in Fraxel laser group (49.2 and 76.8 percent, respectively) than CO2 laser group (36.7 and 44.7 percent, respectively) (P<0.05 for both) Conclusions: Fraxel laser seems to be better than CO2 laser in variant aspects of treatment of leishmaniasis scars